NetAffx GPCR annotation database summary
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چکیده
Only approximately 51% of the human proteome can be annotated by the standard motif-based recognition systems [1]. These systems, currently aggregated into a single distributed system by InterPro [2], include PFAM, PRINTS, ProSite, ProDom, SMART, and SWIS-PROT+TrEMBL. PFAM consists of hidden Markov models based on hand-curated alignments of protein domains. PRINTS is a repository of protein fingerprints, that is, groups of conserved motifs. ProSite is a database of protein families and domains based on common structural motifs. SWIS-PROT is a highly curated and annotated protein sequence database, which is combined with the a computer annotated supplement, TrEMBL. Our goal is to provide a wider base of annotation systems in order to expand the ability to annotate the human proteome.
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